Revelation 11:6

6 These [two witnesses] have power to shut up the sky, so that no rain may fall during the days of their prophesying (their prediction of events relating to Christ's kingdom and its speedy triumph); and they also have power to turn the waters into blood and to smite and scourge the earth with all manner of plagues as often as they choose. 

We have seen the Four Horseman be empowered to kill off a fourth of the earth. We have seen that natural disasters are affecting a third of the earth. We have seen that a spiritual war will kill off a third of all mankind, and now we see that plagues are being spoken out by God’s two witnesses. These two first speak and the things that we have read about happen. They clearly tell the world that the wars are coming and they do. They tell the world that the natural disasters are coming and they do. Can you imagine how these two will be hated by the world for being used in this way? And we will be empowered by the Holy Spirit to agree with them, so imagine how we will be hated as well! The anti-christ and false prophet will be trying to grab all of the worlds power during this time. At every turn these two witnesses will be used by the Holy Spirit to proclaim an event of wrath is coming from our Father and what they are used to proclaim will happen and it will hinder every effort of the anti-christ. These two will proclaim it, we will agree with it, and the world will hate us for it. 

The thing to remember here is that our Father released the Four Horseman. God released the seals, the Angel of the Abyss, the Four Angels at the Euphrates River, and now we are shown that our Father is controlling, through the Holy Spirit, these two witnesses. This is our Father’s wrath and He is in control and His wrath is not against His own body. We are fed by Jesus, covered by Jesus, and find clean water by Jesus. Our sins, sicknesses, and diseases are borne now by our Lord and Savior, and they will be borne during the Great Tribulation by Him as well. Even during the Great Tribulation, Jesus is greater within us then he that is in the world! Also remember that John was told of the speedy victory of Jesus. For the wicked this will be a long 3 1/2 years, but for the Body of Christ it is speedy!